Part Used : ไม่ระบุ
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : Tamarixetin
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 9.32 mg/kg
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Fluvastatin
Dose/Conc.(drug) : 1.5 mg/kg
Remark : Tamarixetin significantly increased the bioavailability of fluvastatin as demonstrated by a 2.2-fold increase in its peak concentration (Cmax) and a 2.4-fold increase in the area under the plasma concentration-time curve (AUCinf) whereas there was no apparent difference in the elimination half-life (T1/2) of fluvastatin between groups. Oral tamarixetin reduced fluvastatin metabolism by about 50% in vivo in the drug absorption phase but did not affect its distribution and disposition.