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Part Used : ผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 50% unripe plantain (standard pellet diet: unripe plantain, 1:1)Duration : blood sample were taken before oral administration of pefloxacin an at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0 and 24.0 h after administered.Type of interaction : PharmacodynamicsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Results: the results indicate the relative extent of bioavailability of pefloxacin in the presence of 50% and 100% unripe plantain respectively, was significantly (p<0.05) greater than that of pefloxacin in the presence of standard pellet feeds. This was reflected by a mean increase of 23% and 45% in area under the curve (AUC 0-24) when pefloxacin was given with 50% 100% unripe plantain respectively. It was also noted that the pefloxacin peak plasma concentration was increase by 19% when given with 50% unripe plantain or 30% when given with 100% unripe plantain. There was no significant change in the mean time to reach peak plasma concentration, a rough estimate of absorption rate.
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 50% unripe plantain (standard pellet diet: unripe plantain, 1:1)Duration : blood sample were taken before oral administration of pefloxacin an at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0 and 24.0 h after administered.Type of interaction : PharmacodynamicsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Results: the results indicate the relative extent of bioavailability of pefloxacin in the presence of 50% and 100% unripe plantain respectively, was significantly (p<0.05) greater than that of pefloxacin in the presence of standard pellet feeds. This was reflected by a mean increase of 23% and 45% in area under the curve (AUC 0-24) when pefloxacin was given with 50% 100% unripe plantain respectively. It was also noted that the pefloxacin peak plasma concentration was increase by 19% when given with 50% unripe plantain or 30% when given with 100% unripe plantain. There was no significant change in the mean time to reach peak plasma concentration, a rough estimate of absorption rate.
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100% unripe plantainDuration : blood sample were taken before oral administration of pefloxacin an at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0 and 24.0 h after administered.Type of interaction : PharmacodynamicsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Results: the results indicate the relative extent of bioavailability of pefloxacin in the presence of 50% and 100% unripe plantain respectively, was significantly (p<0.05) greater than that of pefloxacin in the presence of standard pellet feeds. This was reflected by a mean increase of 23% and 45% in area under the curve (AUC 0-24) when pefloxacin was given with 50% 100% unripe plantain respectively. It was also noted that the pefloxacin peak plasma concentration was increase by 19% when given with 50% unripe plantain or 30% when given with 100% unripe plantain. There was no significant change in the mean time to reach peak plasma concentration, a rough estimate of absorption rate.
Part Used : ผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100% unripe plantainDuration : blood sample were taken before oral administration of pefloxacin an at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0 and 24.0 h after administered.Type of interaction : PharmacodynamicsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Results: the results indicate the relative extent of bioavailability of pefloxacin in the presence of 50% and 100% unripe plantain respectively, was significantly (p<0.05) greater than that of pefloxacin in the presence of standard pellet feeds. This was reflected by a mean increase of 23% and 45% in area under the curve (AUC 0-24) when pefloxacin was given with 50% 100% unripe plantain respectively. It was also noted that the pefloxacin peak plasma concentration was increase by 19% when given with 50% unripe plantain or 30% when given with 100% unripe plantain. There was no significant change in the mean time to reach peak plasma concentration, a rough estimate of absorption rate.