| Synonym |
| Thai / English name |
Part Used : ใบActivity : CYP2D6 INDUCTIONSolvent/Active Compound : Pipermethystine (PM)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kg/dayDuration : 2 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : While pipermethystine (PM) alone demonstrated a nonsignificant increase in CYP1A2, Kava rhizome extract (KRE) and PM + KRE significantly increased hepatic CYP1A2 protein levels by 98% (p < 0.05). CYP2E1 was also increased by 40 to 50% in the KRE and PM + KRE groups, while CYP2D6 protein levels were increased in only PM + KRE group by 50%. CYP3A4 protein levels remained unchanged in all groups.Note : Type of experiment: The rats were randomly split into four treatment groups: (1) control (received corn oil, 3.33 ml/kg/day), (2) pipermethystine (PM) (10 mg/kg/day), (3) Kava rhizome extract (KRE) (100 mg/kg/day equivalent to 63 mg total kavalactones (KL),/kg/day), and (4) PM+ KRE.
Part Used : เหง้าActivity : CYP2D6 INDUCTIONSolvent/Active Compound : acetone-water extract (KRE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg/dayDuration : 2 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : While pipermethystine (PM) alone demonstrated a nonsignificant increase in CYP1A2, Kava rhizome extract (KRE) and PM + KRE significantly increased hepatic CYP1A2 protein levels by 98% (p < 0.05). CYP2E1 was also increased by 40 to 50% in the KRE and PM + KRE groups, while CYP2D6 protein levels were increased in only PM + KRE group by 50%. CYP3A4 protein levels remained unchanged in all groups.Note : Type of experiment: The rats were randomly split into four treatment groups: (1) control (received corn oil, 3.33 ml/kg/day), (2) pipermethystine (PM) (10 mg/kg/day), (3) Kava rhizome extract (KRE) (100 mg/kg/day equivalent to 63 mg total kavalactones (KL),/kg/day), and (4) PM+ KRE.
Part Used : เหง้าActivity : CYP2D6 INDUCTIONSolvent/Active Compound : Pipermethystine (leaves), acetone-water extract (rhizome)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PM 10 mg/kg/day + KRE 100 mg/kg/dayDuration : 2 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : While pipermethystine (PM) alone demonstrated a nonsignificant increase in CYP1A2, Kava rhizome extract (KRE) and PM + KRE significantly increased hepatic CYP1A2 protein levels by 98% (p < 0.05). CYP2E1 was also increased by 40 to 50% in the KRE and PM + KRE groups, while CYP2D6 protein levels were increased in only PM + KRE group by 50%. CYP3A4 protein levels remained unchanged in all groups.Note : Type of experiment: The rats were randomly split into four treatment groups: (1) control (received corn oil, 3.33 ml/kg/day), (2) pipermethystine (PM) (10 mg/kg/day), (3) Kava rhizome extract (KRE) (100 mg/kg/day equivalent to 63 mg total kavalactones (KL),/kg/day), and (4) PM+ KRE.
Part Used : ใบActivity : CYP2D6 INDUCTIONSolvent/Active Compound : Pipermethystine (leaves), acetone-water extract (rhizome)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : PM 10 mg/kg/day + KRE 100 mg/kg/dayDuration : 2 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : While pipermethystine (PM) alone demonstrated a nonsignificant increase in CYP1A2, Kava rhizome extract (KRE) and PM + KRE significantly increased hepatic CYP1A2 protein levels by 98% (p < 0.05). CYP2E1 was also increased by 40 to 50% in the KRE and PM + KRE groups, while CYP2D6 protein levels were increased in only PM + KRE group by 50%. CYP3A4 protein levels remained unchanged in all groups.Note : Type of experiment: The rats were randomly split into four treatment groups: (1) control (received corn oil, 3.33 ml/kg/day), (2) pipermethystine (PM) (10 mg/kg/day), (3) Kava rhizome extract (KRE) (100 mg/kg/day equivalent to 63 mg total kavalactones (KL),/kg/day), and (4) PM+ KRE.
