Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : saponins
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : saponins administered i.p. at 10 mg/kg/day
Duration : 10 days
Type of interaction : Pharmacokinetics
Interaction with drug : Dexamethasone*/Dexamethazone
Dose/Conc.(drug) : -
Remark : Result: Side effects of glycocorticoids are prevented by saponins of G. pentaphyllum. Thus, saponins administered i.p. at 10 mg/kg/day for 10 days to rats that had received dexamethasone i.p. at 10 mg/kg/day for 10 days prevented the side effects of dexamethasone, namely, the adrenal and thymus gland constriction.