ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : CYP3A4 INHIBITION

Solvent/Active Compound : Crude extract was prepared from squeezed juice of Citrus reticulate

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Crude extract prepared from juice of Citrus reticulate exhibited IC50 values of 67.83 +/- 23.23 microgram/mL, compared with that of grapefruit juice crude extract at 76.96 +/- 12.28 microgram/mL. The preincubation of citrus crude extract with cytochrome P450 3A4 in the presence of NADPH led to the enhancement of cytochrome P450 3A4 inhibition. Percent inhibition at the preincubation period of 15 minutes demonstrated 85.03 +/- 3.40% compared with 78.33 +/- 2.09% at 0 minute preincubation period for Citrus reticulate.

Note : Data incomplete

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