Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : Crude extract was prepared from squeezed juice of Citrus reticulate
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Result: Crude extract prepared from juice of Citrus reticulate exhibited IC50 values of 67.83 +/- 23.23 microgram/mL, compared with that of grapefruit juice crude extract at 76.96 +/- 12.28 microgram/mL. The preincubation of citrus crude extract with cytochrome P450 3A4 in the presence of NADPH led to the enhancement of cytochrome P450 3A4 inhibition. Percent inhibition at the preincubation period of 15 minutes demonstrated 85.03 +/- 3.40% compared with 78.33 +/- 2.09% at 0 minute preincubation period for Citrus reticulate.