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Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : Atorvastatin combination with Morus alba leaf extractDuration : -Type of interaction : PharmacodynamicsInteraction with drug : AtorvastatinDose/Conc.(drug) : -Result : PositiveRemark : Atorvastatin treatment of hypercholesterolemic rats in combinaiton with M. alba leaf extract markedly improved cerebellar structure, modulated neurotransmitters, and decreased the incidence of apoptosis.Note : Data from review
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : resveratrolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : Resveratrol has also been shown to reverse drug resistance phenotype of doxorubicin resistant AML-2 myeloid leukemia cells via down-regulation of the expression level and activity of MRP1 transporter molecule.Note : Data from review
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : morinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1 and 25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human hepatic HepG2 and/or Huh7 cells Results: Emodin and morin (conc. 25 micromolar) can effectively activate pregnane X receptor (PXR) in human hepatic HepG2 and/or Huh7 cells. Chrysophanol, physcion, and rhein are also potential activators of PXR.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : mulberroside AType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1 and 25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: LS174T cell lines Results: Emodin, physcion, and rhein significantly induce CYP3A4 mRNA expression in human intestinal LS174T cells. However, mulberroside A significantly down-regulate the expression of PXR in human intestinal LS174T cells.
