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Thai / English name |
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kg three times a dayDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 20 mg/kg (PO)Result : EquivocalRemark : Results: The concentration of midazolam was higher in the animals treated with single-herbal preparations, Mu Dan Pi (Paeonia asperoides), as compared to the control group. The Cmax was indicated to increase 1.5- for Mu Dan Pi, whereas, the Cmax for Xi Yi Hua (Lonicera japonica) and Huang Qin (Scutellana baicalnsis) were similar to the control. The area under the curve (AUC) on the other hand, was also observed the increase of 2- for Mu Dan Pi.
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kg three times a dayDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 20 mg/kg (PO)Result : EquivocalRemark : Results: The concentration of midazolam was higher in the animals treated with single-herbal preparations, Mu Dan Pi (Paeonia asperoides), as compared to the control group. The Cmax was indicated to increase 1.5- for Mu Dan Pi, whereas, the Cmax for Xi Yi Hua (Lonicera japonica) and Huang Qin (Scutellana baicalnsis) were similar to the control. The area under the curve (AUC) on the other hand, was also observed the increase of 2- for Mu Dan Pi.