Part Used : ใบ
Activity : CYP2C6 INDUCTION
Solvent/Active Compound : Terpenes
Type of experiment : in vivo
Type of animal : other
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : -
Duration : 10 days
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : The selected terpenes induced P450 enzymes, as shown by a 53% higher cytochrome P450 content. Western blot studies using human CYP2E1 and rat CYP2C11 and CYP2C6 antibodies gave CYP2E, CYP2C11 and CYP2C6 immunoreactive bands of greater intensity in the test animal vs. control.
Note : Data incomplete
Solvent /active compound: The terpenes chosen were 1,8-cineole, p-cymene, alpha-pinene and limonene.
Type of animal: possums