ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ผล

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : Tamarindus indica L. fruit extract

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 6

N(Treatment) : 6

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Aspirin*/Acetylsalicylic acid/ASA/Ecosprin

Dose/Conc.(drug) : -

Result : Positive

Remark : - The results indicated there was a statistically significant increase in the plasma levels of aspirin and salicylic acid, respectively, when the meal containing Tamarindus indica fruit extract was administered with the aspirin tablets that when taken under fasting state or with the meal without the fruit extract. - The Cmax, AUC0-6h, and t1/2 for aspirin increased from 10.04+/-0.1 mg/ml to 28.62+/-0.21 mg/ml (P<0.05); 14.03+/-0.11 mg/ml. h to 86.51+/-0.21 mg/ml.h (P<0.085) and 1.04+/-0.12 h to 1.50+/-0.44 h (P<0.05) respectively. There was no change in the tmax (0.50+/-0.17 h) but there was a decrease in the Kel from 0.633+/-0.22 to 0.463+/-0.29 (P<0.05). Similarly, the Cmax, AUC 0-6 h and Kel for salicylic acid rose from 43.84+/-0.21 mg/ml to 68.19+/-0.71 mg/ml (P<0.05); 171.59+/-0.07 mg/ml.h to 266.22+/-0.21 mg/ml/.h (P<0.05) and 7.37+/-0.29 to 19.30+/-0.21 (P<0.05), respectively. The tmax decreased from 2.0 +/-0.18 h to 1.0+/-0.08 h (P<0.05) and t1/2 from 0.25+/-0.21 h to 0.184+/-0.11 h (P<0.05).

Note : Data incomplete

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