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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Weakly inhibited CYP1A2 mediated paracetamol formation (IC20 = 63.1 micromolar, IC50>100 micromolar).Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Maslinic acid inhibited CYP2C9-mediated 4-hydroxytolbutamide formation (IC20 = 63.1 micromolar)Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Maslinic acid inhibited CYP2D6 mediated dextrophan formation (IC20 more than 100 micromolar).Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: In pooled human liver microsomes. - Maslinic acid did not significantly affect CYP2E1-mediated 6-hydoxychlozoxazone formation.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Maslinic acid inhibited CYP3A4-mediated 6beta-hydroxytestosterone formation (IC20 = 11.6 micromolar; IC50 = 46.1 micromolar) concentration dependently.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In specified human CYP3A4 isoform. - Maslinic acid inhibited 6beta-hydroxytestosterone formation (IC20 = 4.03 micromolar; IC50 = 62.3 micromolar) concentration dependently in human CYP3A4 isoform.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Oleanolic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Only weakly inhibited CYP1A2 activity by 12.8% at the highest concentration (100 micromolar).Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Oleanolic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Oleanolic acid inhibited CYP2C9 activities is a concentration dependent manner with IC50 13.3 micromolar.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Oleanolic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: In pooled human liver microsomes. - Oleanolic acid did not significantly affect CYP2D6 activities.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Oleanolic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: In pooled human liver microsomes. - Oleanolic acid did not significantly affect CYP2E1 activities.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
