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Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: In pooled human liver microsomes. - Maslinic acid did not significantly affect CYP2E1-mediated 6-hydoxychlozoxazone formation.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound : Oleanolic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: In pooled human liver microsomes. - Oleanolic acid did not significantly affect CYP2E1 activities.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In rat liver microsomes. - Maslinic acid inhibited CYP2E1 mediated 6-hydroxychlorzoxazome formation (IC20 = 9.57 micromolar). - Inhibited rat liver CYP2E1 34.9%Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
