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OLEACEAE Olea europaea L.

Synonym

none ...

Thai / English name

มะกอกฝรั่ง*

[1-1] of 1 article(s) found

หน้า 1

[1] INVESTIGATION OF CYTOCHROME P450 INHIBITORY PROPERTIES OF MASLINIC ACID, A BIOACTIVE COMPOUND FROM OLEA EUROPAEA L., AND ITS STRUCTURE - ACTIVITY RELATIONSHIP.
MIN SUN, YU TANG, TONGGUI DING,ET AL.
PHYTOMEDICINE 2015 Vol.22(),56-65 $54158 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Maslinic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1.25-100 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: In pooled human liver microsomes. - Maslinic acid inhibited CYP2C9-mediated 4-hydroxytolbutamide formation (IC20 = 63.1 micromolar)

Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Oleanolic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1.25-100 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: In pooled human liver microsomes. - Oleanolic acid inhibited CYP2C9 activities is a concentration dependent manner with IC50 13.3 micromolar.

Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.

หน้า 1

EN

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