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Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Weakly inhibited CYP1A2 mediated paracetamol formation (IC20 = 63.1 micromolar, IC50>100 micromolar).Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Oleanolic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In pooled human liver microsomes. - Only weakly inhibited CYP1A2 activity by 12.8% at the highest concentration (100 micromolar).Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Maslinic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.25-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: In rat liver microsomes. - Maslinic acid weakly inhibited CYP1A2 mediated paracetamol formation only at the highest concentration 100 micromolar.Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.
