Synonym |
Thai / English name |
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : Beta-caroteneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : Beta-Carotene has accumulated Rhodamine 123, calcein AM, and doxorubicin in Caco-2 cell dose dependently. It also stimulated the efficacy of 5-Fluorouracil, doxorubicin, and eteposide in Caco-2 cells. Its impact on resistance mechanism involved downregulation of MDR1 gene expression and inhibition of p-glycoprotein transport activity in Caco-2 cells.Note : Data from review
Part Used : ผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Beta-caroteneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : Beta-Carotene has accumulated Rhodamine 123, calcein AM, and doxorubicin in Caco-2 cell dose dependently. It also stimulated the efficacy of 5-Fluorouracil, doxorubicin, and eteposide in Caco-2 cells. Its impact on resistance mechanism involved downregulation of MDR1 gene expression and inhibition of p-glycoprotein transport activity in Caco-2 cells.Note : Data from review