| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : Both sexAge : 2-18 yrsRoute : Oral administrationDose/Conc.(herb) : 40 mg/kg in 2 equally divided dosesDuration : 6 monthsType of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : daunorubicin (1.5 mg/kg, i/v weekly), vincristine (4 mg/kg i/v twice weekly) and prednisolone (5 mg/kg per day orally in 3 divided doses)Result : PositiveRemark : Group III tretment with conventional drugs + Nigella sativa seeds proved best among the three treatments. It is conceivable, therefore, that Nigella sativa seeds could help in treating acute lymphoblastic leukemia in children when given incombination with other cytotoxic drugs.Note : Acute lymphoblastic leukemia (ALL), the selected 48 (16 in each, subjects completed the study were randomly divided into 3 groups. In conventional therapy: group I, daunorubicin (1.5 mg/kg, iv weekly), group II vincristine (4 mg/kg, iv twice weekly) and prednisolone (5 mg/kg/day orally in 3 divided doses) were prescribed to patients of ALL as induction therapy of 3 months. Powdered Nigella sativa seed were given to Group III patients of ALL without L-asparaginase.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : Both sexAge : 2-18 yrsRoute : Oral administrationDose/Conc.(herb) : 40 mg/kg in 2 equally divided dosesDuration : 6 monthsType of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : daunorubicin (1.5 mg/kg, i/v weekly), vincristine (4 mg/kg i/v twice weekly) and prednisolone (5 mg/kg per day orally in 3 divided doses)Result : PositiveRemark : Group III tretment with conventional drugs + Nigella sativa seeds proved best among the three treatments. It is conceivable, therefore, that Nigella sativa seeds could help in treating acute lymphoblastic leukemia in children when given incombination with other cytotoxic drugs.Note : Acute lymphoblastic leukemia (ALL), the selected 48 (16 in each, subjects completed the study were randomly divided into 3 groups. In conventional therapy: group I, daunorubicin (1.5 mg/kg, iv weekly), group II vincristine (4 mg/kg, iv twice weekly) and prednisolone (5 mg/kg/day orally in 3 divided doses) were prescribed to patients of ALL as induction therapy of 3 months. Powdered Nigella sativa seed were given to Group III patients of ALL without L-asparaginase.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : Both sexAge : 2-18 yrsRoute : Oral administrationDose/Conc.(herb) : 40 mg/kg in 2 equally divided dosesDuration : 6 monthsType of interaction : PharmacokineticsInteraction with drug : Prednisolone*/Deltahydrocortisone/MetacortandraloneDose/Conc.(drug) : daunorubicin (1.5 mg/kg, i/v weekly), vincristine (4 mg/kg i/v twice weekly) and prednisolone (5 mg/kg per day orally in 3 divided doses)Result : PositiveRemark : Group III tretment with conventional drugs + Nigella sativa seeds proved best among the three treatments. It is conceivable, therefore, that Nigella sativa seeds could help in treating acute lymphoblastic leukemia in children when given incombination with other cytotoxic drugs.Note : Acute lymphoblastic leukemia (ALL), the selected 48 (16 in each, subjects completed the study were randomly divided into 3 groups. In conventional therapy: group I, daunorubicin (1.5 mg/kg, iv weekly), group II vincristine (4 mg/kg, iv twice weekly) and prednisolone (5 mg/kg/day orally in 3 divided doses) were prescribed to patients of ALL as induction therapy of 3 months. Powdered Nigella sativa seed were given to Group III patients of ALL without L-asparaginase.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : guinea pigType of study : -N(Total) : 35N(Treatment) : 7Sex : Both sexAge : 2-18 yrsRoute : Oral administrationDose/Conc.(herb) : Nigella sativa 0.08 g daily, orallyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Dexamethasone*/DexamethazoneDose/Conc.(drug) : 5 mg/kg i.p.Result : PositiveRemark : The results showed a preventive effect of Nigella sativa on trecheal responsiveness and lung inflammation of sulfur mustard exposed guinea pigs.Note : Guinea pigs were exposed to diluent solution (control group), inhaled SM (SME group), SME treated with Nigella sativa (SME + N), SME treated with dexamethasone (SME + D) and SME treated with both drugs (SME + N + D), (n = 7 for each group) (1) Control group exposed to diluent's solution (ethanol 5 min, 5M, 2F). (2) Sulfur mustard exposed guinea pigs (100 mg/m3 for 5 min, SME group, 3M, 4F). (3) Sulfur mustard exposed guinea pigs pretreated with Nigella sativa 0.08 g daily, orally (SME + N group, 4M, 3F). (4) Sulfur mustard exposed guinea pigs pretreated with 5 mg/kg i.p. dexamethasone 10 min before exposure to sulfur mustard (SME + D group, 3M, 4F). (5) Sulfur mustard exposed guinea pigs pretreated with both Nigella sativa and dexamethasone (SME + N + D group, 5M, 2F).
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 20 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 19 mg/kgResult : PositiveRemark : Type of experiment: xenograft tumor mouse model Results: TQ and 5-FU treatment led to a significant decrease in tumor weight and size compared with the control group.
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 30 (M/F = 16/4)N(Treatment) : 30 (M/F = 16/4)Sex : Both sexAge : 47+/-10.2 yearsRoute : Oral administrationDose/Conc.(herb) : one capsule (450 mg) three times daily after mealsDuration : 3 monthsType of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The only reported drug interaction was hypoglycemia due to concurrent use of insulin and N. sativa, which aggravated its hypoglycemic effects.Note : Subjects: patients with hepatitis C virus (HCV) infection
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Thymoquinone (TQ)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : TQ 50 mg/L in drinking water for 5 days before a single dose of cyclophosphamide (CP) (200 mg/kg, IP)Duration : 5 days, Seven days after the administration of CP, all rats were anesthetized with ether and blood samples were obtained by heart puncture.Type of interaction : PharmacodynamicsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : PositiveRemark : Result: CP reslted in a significant increase in serum creatine kinase, lactate dehydrogenase, cholesterol, triglycerides, creatinine, urea, and tumor necrosis factor-alpha. In heart tissues, CP resulted in a significant increase in thiobarbituric acid reactive substances and total nitrate/nitrite and a significant decrease in reduced glutathione, glutathione peroxidase, catalase, and adenosine triphosphate levels. Interestingly, TQ supplementation resulted in a complete reversal of all the biochemical changes induced by CP to their control values.
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Nigella sativa (NS) oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.2 g/kg amikacin (AMK) was injected i.p., to rats as a single dose. Two dose of NS oil (0.5 mL) were given orally at the day of injection and one day before injection of AMK. The rats were sacrificed on the eighth days.Duration : 8 daysType of interaction : PharmacodynamicsInteraction with drug : AmikacinDose/Conc.(drug) : -Result : PositiveRemark : Result: NS oil significantly decreased the levels of nitric oxide, malondialdehyde and total antioxidant capacity. Furthermore, it increased the level of reduced glutathione. These changes are indicative for lower tissue damage and reduced free radical formation. These results were coinciding with the lower levels of urea, uric acid and creatinine (which were significantly elevated in amikacin treated groups). Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of NS oil in reducing renal damage induced by amikacin.Note : By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: In vitro studies have shown that Nigella sative extracts inhibit cDNA-expressed human cytochrome P-450 3A4, 2C9, 3A5 and 3A7-mediated metabolism of marker substrates therefore may affect and/or inhibit the metabolism of a wide range of drugs.Note : Data from review
