Part Used : เมล็ด
Activity : IMMUNOMODULATOR ACTIVITY
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : guinea pig
N(Total) : 35
N(Treatment) : 7
Sex : Both sex
Age : 2-18 yrs
Route : Oral administration
Dose/Conc.(herb) : Nigella sativa 0.08 g daily, orally
Duration : 14 days
Type of interaction : Pharmacokinetics
Interaction with drug : Dexamethasone*/Dexamethazone
Dose/Conc.(drug) : 5 mg/kg i.p.
Remark : The results showed a preventive effect of Nigella sativa on trecheal responsiveness and lung inflammation of sulfur mustard exposed guinea pigs.
Note : Guinea pigs were exposed to diluent solution (control group), inhaled SM (SME group), SME treated with Nigella sativa (SME + N), SME treated with dexamethasone (SME + D) and SME treated with both drugs (SME + N + D), (n = 7 for each group)
(1) Control group exposed to diluent's solution (ethanol 5 min, 5M, 2F).
(2) Sulfur mustard exposed guinea pigs (100 mg/m3 for 5 min, SME group, 3M, 4F).
(3) Sulfur mustard exposed guinea pigs pretreated with Nigella sativa 0.08 g daily, orally (SME + N group, 4M, 3F).
(4) Sulfur mustard exposed guinea pigs pretreated with 5 mg/kg i.p. dexamethasone 10 min before exposure to sulfur mustard (SME + D group, 3M, 4F).
(5) Sulfur mustard exposed guinea pigs pretreated with both Nigella sativa and dexamethasone (SME + N + D group, 5M, 2F).