Synonym |
Thai / English name |
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : DeoxyelephantopinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-10 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : -Result : PositiveRemark : Deoxyelephantopin weakly inhibits the metabolism of testosterone (IC50 = 14.00 micromolar). Deoxyelephantopin inhibition the metabolism of testosterone (>50%) at concentrations of 10 micromolar and above as compared with ketoconazole, more than 50% of the activity was abolished at 0.5 micromolar and above.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : DeoxyelephantopinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-10 micromolDuration : -Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : -Result : PositiveRemark : Deoxyelephantopin weakly inhibits the metabolism of testosterone (IC50 = 14.00 micromolar). Deoxyelephantopin inhibition the metabolism of testosterone (>50%) at concentrations of 10 micromolar and above as compared with ketoconazole, more than 50% of the activity was abolished at 0.5 micromolar and above.