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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: The average final body weights of the animals significant increases were observed in the groups treated with perilla oil + indomethacin and perilla oil compared with the control group.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : WEIGHT INCREASESolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: The average final body weights of the animals significant increases were observed in the groups treated with perilla oil + indomethacin and perilla oil compared with the control group.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : PROSTAGLANDIN E2 INHIBITIONSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: The serum PGE2 levels tended to decrease on treatment with indomethacin (IM) but were increased by perilla oil compared with the control level. These latter increases tended to be diminished to the control level with the addition of IM (Perilla oil + IM). However, no significant differences were observed between the values.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : GASTROINTESTINAL EFFECTS (UNSPECIFIED)Solvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For colon tumors, perilla oil in combination with indomethacin significantly decreased both the incidence and multiplicity of adenomas in comparison with perilla oil alone. However, strict summation or synergism was not observed.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : ANTITUMOR ACTIVITYSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For colon tumors, perilla oil in combination with indomethacin significantly decreased both the incidence and multiplicity of adenomas in comparison with perilla oil alone. However, strict summation or synergism was not observed.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : CARCINOGENESIS INHIBITIONSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For colon tumors, perilla oil in combination with indomethacin significantly decreased both the incidence and multiplicity of adenomas in comparison with perilla oil alone. However, strict summation or synergism was not observed.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : CARCINOGENIC ACTIVITYSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For lung tumors, the combination of indomethacin and perilla oil caused a significant increase in the multiplicity of lung tumors.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : LUNG PROBLEMS(UNSPECIFIED)Solvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For lung tumors, the combination of indomethacin and perilla oil caused a significant increase in the multiplicity of lung tumors.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : TUMOR PROMOTING EFFECTSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For lung tumors, the combination of indomethacin and perilla oil caused a significant increase in the multiplicity of lung tumors.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : CARCINOGENIC ACTIVITYSolvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For renal cell tumors, a significant increase in the multiplicity of renal cell tumors (adenoma and carcinoma) was observed with perilla oil and indomethacin in combination.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
