Synonym |
Thai / English name |
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 40 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : -Result : PositiveRemark : Route* Intragastric tube - Effect of co-administration of HSE and HCT on diuresis in rats. - Co-administration of the extract (40 mg/kg) with HCT (10 mg/kg) caused a significant increase in the volume of urine excreted, as well as a significant decrease in the pH of urine and the concentrations of sodium bicarbonate and chloride ions.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 40 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : -Result : PositiveRemark : Route* Intragastric tube - Effect of co-administration of HSE and HCT on diuresis in rats. - Co-administration of the extract (40 mg/kg) with HCT (10 mg/kg) caused a significant increase in the volume of urine excreted, as well as a significant decrease in the pH of urine and the concentrations of sodium bicarbonate and chloride ions.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 20 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 20 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 40 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 40 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide