Part Used : เหง้า
Activity : DRUG INTERACTION
Solvent/Active Compound : 1' S-1'-acetoxyeugenol acetate (AEA)
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 0-30 micromolar/L
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : 0-20 micromolar/L
Remark : it was found the AEA was able to reduce the viability levels of MCF-7 cells to a higher extent when used in combination with paclitaxel. Cl analysis indicated that synergistic effects were observed for all combinations of paclitaxel and AEA for 24 h (Cl=0.51-0.66). However, a shift toward an antagonistic effect was observed when treatment of MCF-7 cells was allowed to proceed for 48 h, indicated that this sensitization effect was found to have a transient effect, diminishing upon 48 h of incubation.