Part Used : -
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : EGB761 100 mg/kg/day
Duration : 10 days
Type of interaction : Pharmacokinetics
Interaction with drug : Propranolol*/Propanolol/Beta-propranolol
Dose/Conc.(drug) : -
Remark : Pretreatment of EGB761 at 100 mg/kg for 10 days significantly reduced the area uder the plasma concentration time curve (AUC) and maximum plasma concentration (Cmax) of propranolol, whereas those values of N-desisopropylpropranolol (NDP) were significantly increased.
Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11.
- Data incomplete