ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : hydrogel (mucilage)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : solid dispersion equivalent to 50 mg in 200 mL water

Duration : single dose

Type of interaction : Pharmacokinetics

Interaction with drug : Carbamazepine*/CBZ

Dose/Conc.(drug) : -

Result : Positive

Remark : The Gel was found to be the efficient solubility and bioavailability enhancer for carbamazepine.

Note : Gel = mucilage isolated from the seeds of Ocimum basilicum. Solid dispersion of carbamazepine was prepared by adopting co grinding/ comicronization method. Carbamazepine (CBZ) was co- ground in colloid mill with Gel (in suitable proportion to obtain solid dispersion of CBZ: dried mucilage in 1:1 ratio).

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