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Thai / English name |
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 16 (M/F = 8/8)N(Treatment) : 16 (M/F = 8/8)Sex : Both sexAge : 37.9 +/- 8.6 yearsRoute : Oral administrationDose/Conc.(herb) : 12 ounces of commercially available orange juiceDuration : -Type of interaction : PharmacokineticsInteraction with drug : LevofloxacinDose/Conc.(drug) : 500 mgResult : PositiveRemark : The coadministration of levofloxacin and calcium-fortified orange juice results in a lack of bioequivalence as compared to when it is administered with water in a fasting state. It also demonstrates the ability of nonfortified orange juice to significantly change key pharmacokinetic parameters of levofloxacin.Note : Subjects: healthy volunteers. Each subject received the following dosage regimens in random order: (1) a single 500-mg tablet of levofloxacin with 12 ounces of water, (2) a single 500-mg tablet of levofloxacin with 12 ounces of commercially available orange juice, and (3) a single 500-mg tablet of levofloxacin with 12 ounces of commercially available calcium-fortified orange juice.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 16 (M/F = 8/8)N(Treatment) : 16 (M/F = 8/8)Sex : Both sexAge : 37.9 +/- 8.6 yearsRoute : Oral administrationDose/Conc.(herb) : 12 ounces of commercially available calcium-fortified orange juiceDuration : -Type of interaction : PharmacokineticsInteraction with drug : LevofloxacinDose/Conc.(drug) : 500 mgResult : PositiveRemark : The coadministration of levofloxacin and calcium-fortified orange juice results in a lack of bioequivalence as compared to when it is administered with water in a fasting state. It also demonstrates the ability of nonfortified orange juice to significantly change key pharmacokinetic parameters of levofloxacin.Note : Subjects: healthy volunteers. Each subject received the following dosage regimens in random order: (1) a single 500-mg tablet of levofloxacin with 12 ounces of water, (2) a single 500-mg tablet of levofloxacin with 12 ounces of commercially available orange juice, and (3) a single 500-mg tablet of levofloxacin with 12 ounces of commercially available calcium-fortified orange juice.