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Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 1.92 fold (at 0.5% w/v) and 2.54 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 2.02 fold (at 0.5% w/v) and 3.05 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
