Part Used : ผล
Activity : DRUG INTERACTION
Solvent/Active Compound : Kuguacin J
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 5 and 10 micromolar of kuguacin J
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -
Remark : Co-administration of 5 and 10 micromolar of kuguacin J enhanced the response of KB-V1 cells to vinblastine and paclitaxel, 1.9- and 4.3-fold respectively, for vinblastine, and 1.9- and 3.2-fold respectively, for paclitaxel. The experimental data demonstrated that kuguacin J inhibits the transport activity of p-glycoprotein by directly interacting with substrate binding site of p-glycoprotein.