Part Used : เมล็ด
Activity : CYP2D6 INHIBITION
Solvent/Active Compound : neferine
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Dextromethorphan*/Dextromethorfan/Dextromorphan
Dose/Conc.(drug) : -
Remark : Result: Neferine did not display any remarkable time-dependent or NADPH-dependent inhibition of CYP2D6. These findings may be partially due to the substrate selected for CYP2D6, dextromethorphan. Consequently, from this study, it can be assumed that Neferine displays a weak or negligible inhibition of CYP1A2 and CYP2D6 in vitro.
Note : Phenacetin, dextromethorphan and testosterone, respectively, were used as CYP1A2, CYP2D6 and CYP3A4 substrates, and their metabolites were determined by validated HPLC methodologies.