Part Used : เนื้อหุ้มเมล็ด
Activity : MUSCLE EFFECTS(UNSPECIFIED)
Solvent/Active Compound : pomegranate juice
Type of experiment : human
Type of animal : -
Type of study : Case report
N(Total) : 1
N(Treatment) : 1
Route : Oral administration
Dose/Conc.(herb) : -
Duration : 3 wk
Type of interaction : Pharmacodynamics
Interaction with drug : Ezetimibe
Dose/Conc.(drug) : -
Remark : Pomegranate may increase the risk for rhabdomyolysis during statin therapy, as a result of intestinal CYP3A4 inhibition and increased absorption of active drugs, as commonly reported for grapefruit juice. One case report described a 48 y old man who developed rhabdomyolysis 3 wk after he began drinking pomegranate juice while taking ezetimibe and rosuvastatin for familial hypercholesterolemia.