Part Used : ผล
Activity : CYP1A1 INHIBITION
Solvent/Active Compound : Piperlonguminine
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 0-40 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Phenacetin*/Acetophenetidin
Dose/Conc.(drug) : 20-80 micromolar
Remark : Piperlonguminine (PL) only decreased CYP 1A2-catalyzed phenacetin O-deethylase activity with lC50 values of 10.0 micromolar, whereas the lC50 of PL on CYP1A1-actalyzed phenacetion O-deethylase activity was fivefold higher than the value of CYP1A2. Accordingly, PL was a specific substrate having inhibitiory effects on the CYP1A2 in HLMs, not CYP1A1.