Part Used : ผล
Activity : CYP1A2 INHIBITION
Solvent/Active Compound : Piperlonguminine
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 0-40 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Phenacetin*/Acetophenetidin
Dose/Conc.(drug) : 20-80 micromolar
Remark : The inhibition mechanism was divided into two separate modes based on the Piperlonguminine (PL) concentration in HLMs. At low concentrations (0-16 micromolar; approximately 0.5x, 1x and 2x of lC50), PL was a reversible competitive inhibitor and the Ki value was calculated from a secondary plot with a Ki value of 1.39 micromolar. At high concentrations (16-40 micromolar; approximately as 2x and 5x of lC50), PL was an uncompetitive inhibitor.