Part Used : ไม่ระบุ
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : polyphenols (TP)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Other
Dose/Conc.(herb) : TP400 mg.kg-1
Duration : 14 days
Type of interaction : Pharmacokinetics
Interaction with drug : Lansoprazole
Dose/Conc.(drug) : 8 mg.kg-1
Remark : Route: Intragastrically
- The pharmacokinetic parameters showed that TP decreased the AUC (0-4), Cmax and t1/2z remarkably, increased the AUC (0-4) ratios of 5-hydroxylansoprazole to lansoprazole sulfone significantly (P<0.05), while showed no significant influence on the pharmacokinetics of lansoprazole sulfone (P>0.05). TP could decrease the bioavailability of lansoprazole in rats significantly, which was probably related to the induction of CYP2C19 by TP.