Part Used : หัว
Activity : SERUM LDL LOWERING EFFECT
Solvent/Active Compound : 80% ethanol extract
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 10 mg/kg
Duration : 7 days
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Ezetimibe
Dose/Conc.(drug) : 30 microgram/kg
Remark : The combination of ezetimibe with garlic extract resulted in lowering of serum total body cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol along with increase in serum HDL-cholesterol after treatment.
Note : The animals were randomly divided into seven groups, six animals each. The dosage regimen was as follows: Group I-control, II-fructose (5 g/kg), III-fructose and ezetimibe, IV-fructose and garlic extract, V-fructose, Ezetimibe and garlic extract, VI-Ezetimibe (30 microgram/kg) and VII-garlic extract (10 mg/kg).