ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : Garlic extract

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 500 mg/kg

Duration : 8 days

Type of interaction : Pharmacokinetics

Interaction with drug : Metformin

Dose/Conc.(drug) : 320 mg/kg

Result : Positive

Remark : Garlic is altering the pharmacokinetics of Metformin in rats by significantly increasing its Cmax and AUC0-12h. With repeated dose administration, a prominent effect is seen by a significant increase in Cmax, AUC0-12h and slight increase in t1/2.

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